本网讯日前，我院分析化学专业姚守拙院士和谢青季教授指导的博士生傅迎春等的最新研究成果正式发表在国际著名杂志《Advanced Functional Materials》上 ，该杂志2007年影响因子为7.496。参加该论文研究工作的其他研究生是李鹏昊，徐霞红（湖南大学），雷丽红，陈超，邹灿，邓文芳等。

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论文题目：One-Pot Preparation of Polymer-Enzyme-Metallic Nanoparticle Composite Films for High-Performance Biosensing of Glucose and Galactose
杂志名称：Advanced Functional Materials
论文作者：Yingchun Fu, Penghao Li, Qingji Xie, Xiahong Xu, Lihong Lei, Chao Chen, Can Zou, Wenfang Deng, Shouzhuo Yao

论文摘要：New polymer-enzyme-metallic nanoparticle composite films with a high-load and a high-activity of immobilized enzymes and obvious electrocatalysis/nano-enhancement effects for biosensing of glucose and galactose are designed and prepared by a one-pot chemical pre-synthesis/electropolymerization (CPSE) protocol. Dopamine (DA) as a reductant and a monomer, glucose oxidase (GOx) or galactose oxidase (GaOx) as the enzyme, and HAuCl₄ or H₂PtCl₆ as an oxidant to trigger DA polymerization and the source of metallic nanoparticles, are mixed to yield polymeric bionanocomposites (PBNCs), which are then anchored on the electrode by electropolymerization of the remaining DA monomer. The prepared PBNC material has good biocompatibility, a highly uniform dispersion of the nanoparticles with a narrow size distribution, and high load/activity of the immobilized enzymes, as verified by transmission/scanning electron microscopy and electrochemical quartz crystal microbalance. The thus-prepared enzyme electrodes show a largely improved amperometric biosensing performance, e.g., a very high detection sensitivity (99 or 129 µA cm^-2 mM^-1 for glucose for Pt PBNCs on bare or platinized Au), a sub-micromolar limit of detection for glucose, and an excellent durability, in comparison with those based on conventional procedures. Also, the PBNC-based enzyme electrodes work well in the second-generation biosensing mode. The proposed one-pot CPSE protocol may be extended to the preparation of many other functionalized PBNCs for wide applications.

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